2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-180700
    2'-Deoxy-5-hydroxymethyl-CTP
    2'-Deoxy-5-hydroxymethyl-CTP is a nucleoside metabolite.
    2'-Deoxy-5-hydroxymethyl-CTP
  • HY-153059
    5-(N-Methyl-N-trifluoroacetyl)aminomethyl uridine
    5-(N-Methyl-N-trifluoroacetyl)aminomethyl uridine is a nucleoside compound.
    5-(N-Methyl-N-trifluoroacetyl)aminomethyl uridine
  • HY-154024
    N4-Benzoyl-2’-O-(2-methoxyethyl)cytidine
    N4-Benzoyl-2’-O-(2-methoxyethyl)cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N4-Benzoyl-2’-O-(2-methoxyethyl)cytidine
  • HY-122524AS
    7-Methylguanosine-13C,d3 iodide
    7-Methylguanosine-13C,d3 iodide is the 13C- and deuterium labeled 7-Methylguanosine iodide (HY-122524A). 7-Methylguanosine iodide is an iodide of 7-Methylguanosine (HY-122524). 7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects.
    7-Methylguanosine-<sup>13</sup>C,d<sub>3</sub> iodide
  • HY-152375
    8-Hydroxy-xyloguanosine
    8-Hydroxy-xyloguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Hydroxy-xyloguanosine
  • HY-138584
    IBU-DC Phosphoramidite
    IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.
    IBU-DC Phosphoramidite
  • HY-152475
    2’-β-C-Ethynyladenosine
    2’-β-C-Ethynyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-β-C-Ethynyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    2’-β-C-Ethynyladenosine
  • HY-152594
    Uridine-5-oxyacetic acid
    Uridine-5-oxyacetic acid is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Uridine-5-oxyacetic acid
  • HY-180737
    5-Hydroxyindolepyruvate
    5-Hydroxyindolepyruvate is a nucleoside metabolite.
    5-Hydroxyindolepyruvate
  • HY-154307
    4′,5′-Didehydro-5′-deoxy-2′-O-methyluridine
    4′,5′-Didehydro-5′-deoxy-2′-O-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4′,5′-Didehydro-5′-deoxy-2′-O-methyluridine
  • HY-152540
    5-Methoxy-4-thiouridine
    5-Methoxy-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Methoxy-4-thiouridine
  • HY-154148
    N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine
    N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine
  • HY-152505
    5-Methyl-4-thiouridine
    5-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Methyl-4-thiouridine
  • HY-154144
    2’,3’,5’-Tri-O-benzoyl-2’-β-C-methyl-5-methyl uridine
    2’,3’,5’-Tri-O-benzoyl-2’-β-C-methyl-5-methyl uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    2’,3’,5’-Tri-O-benzoyl-2’-β-C-methyl-5-methyl uridine
  • HY-152731
    3′-Deoxy-3′-methylcytidine
    3′-Deoxy-3′-methylcytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3′-Deoxy-3′-methylcytidine
  • HY-154491
    5’-Deoxy-5-methyluridine
    5’-Deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-Deoxy-5-methyluridine
  • HY-152801
    5-Naphthyl-β-methylaminocarbony-3’-O-acetyl-2’-O-methyluridine
    5-Naphthyl-β-methylaminocarbony-3’-O-acetyl-2’-O-methyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Naphthyl-β-methylaminocarbony-3’-O-acetyl-2’-O-methyluridine
  • HY-154130
    1-(b-D-Xylofuranosyl)-5-trifluoromethyluracil
    1-(b-D-Xylofuranosyl)-5-trifluoromethyluracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-(b-D-Xylofuranosyl)-5-trifluoromethyluracil
  • HY-180655
    15-Hydroxy-5,6-oxido-7,9,11,13-eicosatetraenoic acid
    (5,6)-Epoxytetraene is a precursor of the trapping product in the biosynthesis of lipoxins in human leukocytes.
    15-Hydroxy-5,6-oxido-7,9,11,13-eicosatetraenoic acid
  • HY-154597
    2’-Chloro-N6-benzyl adenosine
    2’-Chloro-N6-benzyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2’-Chloro-N6-benzyl adenosine